-微健康基因

科学研究

微生态相关的数据分析和成果转化

共同设计研究方案

个性化数据分析
和图表制作

科研成果转化应用

微生态干预临床试验服务

获得更多适应症的临床证据

与微生态儿科专家紧密合作

快速产出对应产品背书成果

知识共享和培训

线上分享:总结妇幼儿微生态和基因研究和应用进展

线下沙龙:面对面与专家互动,解决研究中面临的真实问题

线下培训班:解读医学微生态数据挖掘和文章设计

科研团队介绍

团队具有平均7年以上的微生物和菌群生物信息与数据挖掘经验,曾参与或主导了欧盟MetaHIT肠道菌群参考集、神州飞船搭载病原菌变异研究、耶尔森鼠疫菌群体进化、结核分枝杆菌群体耐药分析、德国大肠杆菌致病机制研究、国际疫霉大联盟菌谱功能及特性分析等重大项目,相关成果发表于新英格兰医学(NEJM)、Nature、Science、Nature Genetics、Nature Communications、PNAS、ISMEJ等学术期刊。自2015年6月成立公司以来,一直专注儿科相关的微生物、菌群和相关宿主互作的研究。

团队成员的部分大项目经历:

1.Zhang H, Li D, Zhao L, et al. Genome sequencing of 161 Mycobacterium tuberculosis isolates from China identifies genes and intergenic regions associated with drug resistance.[J]. Nature Genetics, 2013, 45(10):1255-1260.(IF=29.6, 共同第一作者)

2.Cui Y, Yu C, Yan Y, Li D, et al. Historical variations in mutation rate in an epidemic pathogen, Yersinia pestis[J]. Proceedings of the National Academy of Science, 2013, 110(2):577-582. (IF=9.68,共同第一作者)

3.Rohde H, Qin J, Cui Y, Li D, et al. Open-source genomic analysis of Shiga-toxin-producing E. coli O104:H4[J]. New England Journal of Medicine, 2011, 365(8):718-724. (IF=53.484,共同第一作者)

4.Zhou H W, Li D F, Tam F Y, et al. BIPES, a cost-effective high-throughput method for assessing microbial diversity[J]. Isme Journal Multidisciplinary Journal of Microbial Ecology, 2011, 5(4):741-749.(IF=7.4)

5.Qin J, Li R, Raes J,..., Li D et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature 464, 59-65[J]. Nature, 2010, 464(7285):59-65.(IF=36.101,署名作者)

6.Liu Y, Zhou Q, Wang Y, et al. Gekko japonicus genome reveals evolution of adhesive toe pads and tail regeneration[J]. Nature Communications, 2015, 6:10033.(IF=12,共同第一作者)

7.Chen S, Zhang G, Shao C,…, Zhou Q,et al. Whole-genome sequence of a flatfish provides insights into ZW sex chromosome evolution and adaptation to a benthic lifestyle[J]. Nature Genetics, 2014, 46(3):253-260.(IF=29.6, 署名作者)

8.Fang X, Nevo E, Han L, Jiang X, et al. Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax.[J]. Nature Communications, 2014, 5(3966):3966.(IF=12,共同第一作者)

9.Wang X, Fang X, Yang P, Jiang X, et al. The locust genome provides insight into swarm formation and long-distance flight.[J]. Nature Communications, 2014, 5(5):2957. (IF=12,共同第一作者)

10.Zhang G, Fang X, Guo X,..., Jiang X et al. The oyster genome reveals stress adaptation and complexity of shell formation[J]. Nature, 2012, 490(7418):49-54. (IF=36,署名作者)

11.Zhang G, Cowled C, Shi Z,..., Jiang X et al. Comparative analysis of bat genomes provides insight into the evolution of flight and immunity[J]. Science, 2013, 339(6118):456-60. (IF=31.5,署名作者)

微健康基因儿科微生态相关成果:

1.Wang H, Dai W, Feng X, et al. Microbiota Composition in Upper Respiratory Tracts of Healthy Children in Shenzhen, China, Differed with Respiratory Sites and Ages. Biomed Research International, 2018, doi: 10.1155/2018/6515670.

2.Dai W, Wang H, Zhou Q, et al. The Concordance between Upper and Lower Respiratory Microbiota in Children with Mycoplasma Pneumoniae Pneumonia. Emerging Microbes & Infections, 2018, 7(1):92.

3.Bao Y, Li Y, Qiu C, et al. Bronchoalveolar lavage fluid microbiota dysbiosis in infants with protracted bacterial bronchitis[J]. Journal of Thoracic Disease, 2018, 10(1):168-174.

4.Liu SX, Li YH, Dai WK, Li XS, Qiu CZ, Ruan ML, Zou B, Dong C, Liu YH, He JY, Huang ZH, Shu SN. Fecal microbiota transplantation induces remission of infantile allergic colitis through gut microbiota re-establishment. World J Gastroenterol 2017; 23(48): 8570-8581

5.Lu Z, Dai W, Liu Y, et al. The alteration of nasopharyngeal and oropharyngeal microbiota in children with MPP and Non-MPP.[J]. Genes, 2017, 8(12):380.

6.Hu Q, Dai W, Zhou Q, et al. Dynamic oropharyngeal and faecal microbiota during treatment in infants hospitalized for bronchiolitis compared with age-matched healthy subjects.[J]. Scientific Reports, 2017, 7(1):11266.

7.Xie G, Zhou Q, Qiu C Z, et al. Ketogenic diet poses a significant effect on imbalanced gut microbiota in infants with refractory epilepsy[J]. World Journal of Gastroenterology, 2017, 23(33):6164-6171.

8.Liu M Y, Yang Z Y, Dai W K, et al. Protective effect of Bifidobacterium infantis CGMCC313-2 on ovalbumin-induced airway asthma and β-lactoglobulin-induced intestinal food allergy mouse models.[J]. World Journal of Gastroenterology, 2017, 23(12):2149-2158.

9.Wang H, Li Y, Feng X, et al. Dysfunctional gut microbiota and relative co-abundance network in infantile eczema[J]. Gut Pathogens, 2016, 8(1):36.

10.Wang H, Dai W, Qiu C, et al. Mycoplasma pneumoniae and Streptococcus pneumoniae caused different microbial structure and correlation network in lung microbiota[J]. Journal of Thoracic Disease, 2016, 8(6):1316.

11.Yang Z, Guo Z, Qiu C, et al. Preliminary analysis showed country-specific gut resistome based on 1,267 feces samples[J]. Gene, 2016, 581(2):178-182.

12.王文建, 周潜, 戴文魁,等. 难治性癫痫婴幼儿肠道菌群的变化[J]. 中国微生态学杂志, 2017, 29(5):502-505.

13.黄文献, 王和平, 王玉蕾,戴文魁, 等. 高通量测序检测肺炎婴幼儿抗生素治疗前后肠道菌群变化[J]. 中国微生态学杂志, 2016, 28(5):497-500.

14.孙玲玲,李喜亮,卢志威,周潜, 等. 肺炎支原体肺炎患儿口咽部菌群的改变[J].中国微生态学杂志, 2018.

15.刘孝荣, 马东礼, 姜含芳,等. 高通量测序方法在重症肺炎病原体检测的应用[J]. 中华检验医学杂志, 2017, 40(8).

公司平台和合作单位

儿科专家工作站

微生态与儿童健康
关联研究实验室

中华医学会儿科学分会
呼吸学组微生态协作组成员
消化学组微生态协作组成员